Diverse heterogeneous systems that process digital information are critical factors behind an industry’s success. However, their diversity calls for standard protocols to pass massive, sometimes complex data sets through them. For years now, an open middleware protocol, called the Advanced Message Queuing Protocol (AMQP), is available to manage the messaging needs of non-compatible digital systems. However, AMQP appears to be less exploited than its potential in the industry now. Hence, this study explores emboldening interest, innovation, and investment by accentuating the core principles, success stories, and numerous integration possibilities with AMQP. The study reaches the background, overview, architecture patterns, and working methodology of AMQP. It describes the successful solutions built around AMQP and suggests further integration opportunities using AMQP based messaging. The study highlights AMQP solutions in practice and potential integration strategies using AMQP. With ongoing innovation, a flood of devices and systems have become ready to integrate and feed the cloud. The ubiquitous cloud is the place for all-size businesses, provided the connectivity comes cheaper, better, and quicker. Turning their focus onto the AMQP, the organizations can position themselves for better trade and commoditize their offerings competitively.